This article describes a method that can be used in experimental dentistry for investigations of osteointegration processes of dental implants. The procedure was patented (Patent BOPI AGEPI MD nr.12.2010). The researches accomplished below represent a component part of the subject area consecrated to the Evaluation of coordinative compounds of Zink and Vanadium at the stimulation of osteo-regenerative processes in periodontal tissues and at the application of dental implants. The experimental investigation included experiments carried out on 280 white rats. There were taken for the study 24 substances that contained Zink, Vanadium and Nickel. Testing of the influence of some new coordinative compounds of transitive metals (Zn, V, Ni) on osteo-regenerative processes in normal physiological conditions was determined in bone tissues of periodontium and femoral bones were extracted later on used for the determination of principal biochemical indices of bone tissue. There has been determined the most active biologic coordinative compound Zn(CF3CO2)2(γPic)2 (Patent Nr. 950188 AGEPI MD) in regenerative processes of periodontal tissues during the modeling of experimental periodontitis. The detailed study of the influence of the coordinative compounds of Zn and V that have a better biological activity was executed on the rats that had been inserted dental implants made out of Titan. Before the application of the treatment and at the end of the treatment with the above mentioned compounds, there were made blood tests of every rat on hemolymphogram of hematologic analyzer PCE-170 ERMA Japan. There was elaborated a new method of modeling experimental periodontitis at laboratory animals (Patent Nr. 5388 din 2008.01.14, RM). There were studied the following biochemical parameters: alkaline phosphatase, acid phosphatase, substances with medium and small molecular mass (SMSM), necrotic substances (NS), carnosine, nitric oxide, adenosine deaminase, adenylate deaminase. There were accomplished radiovisiographic densitograms. Investigational methods of patients with periodontal diseases and dental implants. The examination was carried out in accordance with the algorithm of estimation of contraindications and indications suggested by us while inserting dental implants. The elaboration of the algorithm became possible on the base of the experience in insertion of implants Alpha Bio; MIS; Alpha Dent; CeraRoot Zirconium Oxide Dental Implants; and the procedures elaborated by us (patent Nr. 2379 from 2004.02.29; patent Nr.8,AGEPI MD from 2008-02-18). 57 patients with diverse periodontal diseases were subjected to the study. A profound investigation of biochemical indices of 27 patients was accomplished; out of them 15 patients were inserted dental implants. Zink picolinate was administrated per os 1 x 3 times a day before meals. The duration of the treatment was 30 days.