Pollution is one of the biggest problems the world is facing today. Due to anthropogenic activities like population growth, urbanization, industrialisation and agricultural activity, the pollution is increasing with every passing year. The living organism can be effected by the rise in pollutant’s concentrations. The potential adverse effect of PPCPs like, pharmaceuticals, veterinary drugs, pesticides, and personal care products on organism, human health and ecoysystem can be seen. Much of the previous work has showed that most of the pharmaceuticals are excreted from the body without any changes and causing serious problems for aquatic flora, fauna, and both plants and animals receiving natural water. In our study Triticum aestivum L. was used as model organisms. Mineral elements intake levels of stem parts of wheat were studied with different concentrations of the drug substances such as Acetaminophen and Caffeine. For this, different concentrations (control, 15 mg, 50 mg, and 200 mg) of Acetominophen, (control, 50 mg, 100 mg, and 300 mg) of Caffeine has been added to wheat grown soil. Wheat were harvested after 15 days. The collected samples were then pretreated in a laboratory and ICP-OES elemental analysis was performed. The obtained data were evaluated and and the sowing differences between experimental groups were studied to determine. As result, due to increased medical concentrations, uptake of mineral elements in wheat was determined to be decreased. Via our studies, pharmaceutical agents mixed into soil was determined to be effective in the development of wheat and mineral element uptake this plant thus, to prevent the cropp losses and to prevent negative effects on the food chain and other creatures, the environmental impact of these contaminants should be minimized. It is very important for the implementation of legal regulations with precision.