Among the modern agrotechnologies aimed at increasing agricultural plants productivity and crop quality, complex biopreparations based on agronomically useful microorganism associations and their metabolites take the significant place. These bioformulations make it possible to obtain ecologically friendly production and they are an integral part of organic farming. Bacterial bioformulation Ecophosphoryn for cereals, technical, vegetable and other crops has been developed at the D.K. Zabolotny Institute of Microbiology and Virology of the National Academy of Science of Ukraine. It has received the Quality Certificate “Organic Standard” for use in organic agriculture (according to the IACB Equivalent European Union Organic Production and Processing Standard to the Regulations EU No. 834/2007 and No. 889/2008). Ecophosphoryn components are strains of soil phosphate-mobilizing and nitrogen-fixing bacteria with a wide range of agronomically useful properties: the ability to mobilize insoluble organophosphates, fix the atmospheric nitrogen, synthesize a complex of biologically active substances, including exopolysaccharides, phytohormones, and antibiotic compounds for the phytopathogens biocontrol. Strains-bioagents also have a urease activity, ability to bioremediate radionuclide contaminated soils, and a resistance to chemical fungicides. It allows using Ecophosphoryn in integrated plant protection technologies. Ecophosphoryn phytostimulating and biocontrolling activity has been shown in laboratory, vegetative and field experiments on buckwheat, barley, wheat, maize, sunflower, flax, cabbage, tomato and other crops. Under the inoculation of the seeds of Podolianka cultivar winter wheat with Ecophosforyn, a stimulation of development of a photosynthetic apparatus has been observed. The leaf area on one plant, the accumulation of chlorophyll in leaves and the productivity of photosynthetic activity of a leaf surface unit have increased by 20%, 40% and more than 30%, respectively. The harvest of grain has increased by 25%, wherein the quality of grain has improved (weight of thousand grains and grain nature). The pre-sowing seeds treatment with Ecophosphoryn has contributed to the increase in the grain yield of Rannia 93 cultivar spring wheat by 10-19% (3-6 c/ha). Ecophosphoryn used during the sunflower growing season has contributed to the increase in yield by 300 kg/ha. Ecophosphoryn joint use with Maxim XL 035 FS fungicide (with 0.1 application rate) in the arid vegetation period conditions has effectively protected the crops from fusarial-helminthosporous root decay and contributed to a significant increase in the yield of Myronivska 65 cultivar winter wheat by 2.6 c/ha. High efficiency has been shown by Ecophosphoryn in a combination with fungicide Acrobat MC with a reduced by 25% rate of consumption on tomatoes of Flora cultivar. The average efficiency against tomato alternaria was 72.9% compared to 73.4% in a variant with a fungicide with a full rate of consumption, wherein the yield by 15% has increased. Thus, thanks to the multi-vector beneficial effect on plants, Ecophosphoryn helps to improve their nutrition, increase their immune status and stress resistance, control phytopathogens, activate development of microbial-plant systems, increase productivity and crop quality.