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SM ISO690:2012 NARIMANOVA, G., AHMADOVA, Gunay. Level of Vascular Endothelial Growth Factor, Carcinoma Embryonic Antigen, Calcium and Phosphorus in Blood Serum in Different Types of Bone Tumors. In: Curierul Medical, 2011, nr. 2(320), pp. 6-10. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 2(320) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 6-10 | ||||||
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Background: The extent of angiogenesis seems to be an essential prognostic factor in many solid tumors of children and adults. Vascular
endothelial growth factor (VEGF) is a proangiogenic cytokine that is highly expressed in many solid tumors often correlating with a poor
prognosis. Aim: The aim of the study was to assess the angiogenesis on the basis of serum VEGF levels and also to compare the concentrations
in serum of carcinoma embryonic antigen, oxyproline, calcium and phosphorus in different types of bone tumors. Patients and Methods: The
research was conducted on 66 patients and also 22 healthy individuals, who were accepted to our clinic. Patients were divided into three groups:
primary bone cancer (n = 22), bone metastasis (n = 22), and benign bone tumors (n = 22). Results: VEGF, CEA and oxyproline concentrations
were increased in both primary bone tumors and bone metastasis in comparison with healthy individuals and patients with benign tumors
(p < 0.05). However, we found statistically significant higher phosphorus levels in all patient groups (p < 0.05), and higher calcium only in the
bone metastasis group as compared with controls (p < 0.05). A significant positive correlation existed between VEGF and CEA. Conclusions:
High VEGF levels, as a marker of angiogenesis, were associated with primary bone tumors and bone metastasis. The calcium and phosphorus
content, in addition to VEGF, CEA and oxyproline levels, could be useful in prognosis and differentiation of the bone tumors. Future studies in
larger series are needed to confirm these data. |
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Cuvinte-cheie bone tumors, cancer embryonic antigen, oxyproline, angiogenesis, vascular endothelial growth factor |
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