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SM ISO690:2012 TOFAN, Elena, GONCIAR, Veaceslav, БУТОРОВ, Иван, NECULA, Gheorghe, КОЩУГ, Ион. Сравнительная эффективность лозартана и лизиноприла в терапии хронической сердечной недостаточности. In: Curierul Medical, 2010, nr. 5(317), pp. 15-19. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 5(317) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 15-19 | ||||||
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E. Tofan, V. Gonciar, I. Butorov, G. Necula, I. Cosciug
Comparative Efficiency of Losartan and Lisinopril in the Treatment of Chronic Heart Failure
The aim of the work was to appreciate the influence of the antagonist of AT I receptors Losartan on the hemodynamics and morphofunctional
parameters of the heart. Were examined 50 patients with chronic heart failure (CHF) of III functional class (FC) and the ejection fraction of
the left ventricle (L. V) less then 45%, with average age – 62.1 ± 2.4 years old. All patients formed 2 groups: patients from the 1st group (n = 25)
took 50 mg of Losartan once in 24 hours, the 2nd (n = 25) – Lisinopril 10 mg. The treatment lasted 24 weeks. By the results of the study, it was
established that Losartan provoked a more efficient diminishing of the clinical symptoms of CHF in comparison with Lisinopril, the diminishing
of the left atrium and ventricle in size and contractility enhancement of the left ventricle. |
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Cuvinte-cheie chronic heart failure, Losartan, myocardium remodeling, Lisinopril |
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