Objectіve. Calculation of predictive value, sensitivity and specificity of the diagnostic test ActimPROM for premature rupture of membranes detection. Material and methods. In prospective study 27 pregnant women between 24 and 41 gestational weeks who have been admitted to the Donetsk Regional Center for Maternal and Child Protection during June 1- August 1, 2011 with suspected premature rupture of the membranes (PROM) without uterine contractions were included. “Fern” test and ActimPROM have been used. The tests diagnostic capabilities were calculated in comparison to final clinical diagnosis of PROM. Both tests prognostic values were compared. Sensitivity, specificity and predictive value of the tests were evaluated by statistical package MedStat (Lyakh J.E., Gurianov V.G., 2004-2012) using logistic regression and constructing ROC - curve. p<0,05 was considered statistically significant.16 Results. On admission there was: in 21 cases suspected and in 6 – obvious leakage of water due to premature rupture of the membranes. Test ActimPROM has demonstrated sensitivity of 100% (95% CI, 82.4% -100%), specificity - 83.,3% (95% CI 35,9% -99,6%), the likelihood ratio LR = 6,0 (95% CI 1,0-35,9). The “fern” test sensitivity was 73,7% (95% CI 48,8% -90,9%), specificity - 33,3% (95% CI 4,3% -77,7%), the likelihood ratio LR = 1,1 (95% CI 0,6-2,1). -LR = 0,8 (95% CI 0,2-3,1). According to logistic regression analysis, the “fern” test is unsuitable for PROM detection. Conclusions. Use of ActimPROM test increases precision of premature rupture of the membranes diagnosis. Simplicity and speed in getting the test results let us to recommend its use in obstetric practice. We do not recommend use of the “fern” test in view of its low diagnostic properties. Objectіve. Calculation of predictive value, sensitivity and specificity of the diagnostic test ActimPROM for premature rupture of membranes detection. Material and methods. In prospective study 27 pregnant women between 24 and 41 gestational weeks who have been admitted to the Donetsk Regional Center for Maternal and Child Protection during June 1- August 1, 2011 with suspected premature rupture of the membranes (PROM) without uterine contractions were included. “Fern” test and ActimPROM have been used. The tests diagnostic capabilities were calculated in comparison to final clinical diagnosis of PROM. Both tests prognostic values were compared. Sensitivity, specificity and predictive value of the tests were evaluated by statistical package MedStat (Lyakh J.E., Gurianov V.G., 2004-2012) using logistic regression and constructing ROC - curve. p<0,05 was considered statistically significant. Results. On admission there was: in 21 cases suspected and in 6 – obvious leakage of water due to premature rupture of the membranes. Test ActimPROM has demonstrated sensitivity of 100% (95% CI, 82.4% -100%), specificity - 83.,3% (95% CI 35,9% -99,6%), the likelihood ratio LR = 6,0 (95% CI 1,0-35,9). The “fern” test sensitivity was 73,7% (95% CI 48,8% -90,9%), specificity - 33,3% (95% CI 4,3% -77,7%), the likelihood ratio LR = 1,1 (95% CI 0,6-2,1). -LR = 0,8 (95% CI 0,2-3,1). According to logistic regression analysis, the “fern” test is unsuitable for PROM detection. Conclusions. Use of ActimPROM test increases precision of premature rupture of the membranes diagnosis. Simplicity and speed in getting the test results let us to recommend its use in obstetric practice. We do not recommend use of the “fern” test in view of its low diagnostic properties.

Obiectuvul. Calcularea valorii predictive, sensibilităţii şi specificităţii testului ActimPROM pentru diagnosticarea rupturii premature a membranelor (RPM). Materiale şi metode. Studiul prospectiv a inclus 27 de femei gravide între 24 şi 41 de săpt. de sarcina, care au fost admise la Centrul Regional din Donetsk pentru Ocrotirea Mamei şi Copilului în perioada 1 iunie - 1 august, 2011, cu suspecţie la ruptura prematură a membranelor fără contracţii uterine. Testele "Fern" şi ActimPROM au fost utilizate. Capacităţile de diagnostic ale testelor s-au calculat în comparaţie cu diagnosticul clinic final de RPM. Valorile prognostice ale ambelor teste au fost comparate. Sensibilitate, specificitate şi valoarea predictivă a testelor au fost evaluate prin pachetul statistic MedStat (Lyakh JE, Gurianov VG, 2004-2012) folosind regresia logistică şi construirea curbii ROC. p<0,05 a fost considerat statistic semnificativ. Resultate. La internare s-au înregistrat: 21 de cazuri de suspecţie şi 6 cazuri de scurgere evidentă a lichidului ca urmare a rupturii premature a membranelor. Testul ActimPROM a demonstrat sensibilitate de 100% (95% CI, 82.4%-100%), specificitate – 83.3% (95% CI 35,9%-99,6%), raportul probabilităţii LR = 6,0 (CI 95%, 1,0-35,9). Sensibilitatea testului "fern" a fost de 73,7% (95% CI 48,8%-90,9%), specificitate - 33,3% (95% CI 4,3%-77,7%), raportul probabilităţii LR = 1,1 (95% CI 0,6-2,1). -LR = 0,8 (95% CI 0,2-3,1). Conform analizei de regresie logistică, testul "fern" nu este potrivit pentru detectarea RPM. Concluzii. Utilizarea testului ActimPROM creşte precizia diagnosticului de RPM. Simplicitatea şi viteza în obţinerea rezultatelor testului ne permite a-l recomanda pentru utilizare în practică obstetricală. Noi nu recomandăm utilizarea testului "fern", având în vedere proprietăţile sale reduse de diagnostic