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Ultima descărcare din IBN: 2024-02-18 13:28 |
SM ISO690:2012 ŞAPTEFRAŢI, Lilian. Limfangiogeneza normală şi tumorală
. In: Curierul Medical, 2009, nr. 3(309), pp. 45-52. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(309) / 2009 / ISSN 1875-0666 | ||||||
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Pag. 45-52 | ||||||
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Normal and Tumoral Lymphangiogenesis
In many malignant tumours the lymphatic system represents the main path for metastatic dissemination of the tumor cells in the lymph nodes.
As is well known, the status of the lymph nodes is the prognostic factor in numerous human tumors and has great importance in establishing of the
therapeutic strategy. Nevertheless, recent scientific data about lymphatic metastases, especially in the early stages of the tumoral proliferation, is
insufficient. It is known that metastases of the tumour cells involve blood and lymphatic vascular systems. Tumoral cells influence these systems
via secretion of growth factors necessary for formation of certain vascular networks which may facilitate the spread of metastasis. It is not yet
clear, however, whether tumor cells invade the existent peripheral lymphatic vessels or invade the newly-created vessels which are formed during
tumoral lymphangiogenesis. This is due to the later introduction of specific markers for lymphatic endothelium, insufficient knowledge of the
factors which are implicated in the lymphangiogenesis, and the absence of experimental models which can permit the quantitative evaluation
of metastases in the lymph nodes. Molecular control of the tumoral lymphangiogenesis and knowledge of the mechanism of lymphatic tumoral
metastasis will offer new therapeutic tactics in treating human cancer. The aim of the study was the critical analysis of the literature regarding
the structure, functions, and development of lymphatic vessels and their importance in tumoral pathology. Current understanding of the roles
of lymphangiogenic factors, the mechanism of lymphatic metastases, and the inhibited therapeutic opportunity of lymphangiogenesis will also
be presented.
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Cuvinte-cheie lymphatic endothelial cell, lymphangiogenesis, cancer |
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