Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
815 2 |
Ultima descărcare din IBN: 2024-03-20 17:14 |
SM ISO690:2012 ŞAPTEFRAŢI, Lilian. Progresia neoplaziei de cervix uterin şi activarea limfangiogenezei
. In: Curierul Medical, 2009, nr. 2 (308), pp. 8-10. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 2 (308) / 2009 / ISSN 1875-0666 | ||||||
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Pag. 8-10 | ||||||
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Progression of Neoplasm in the Cervix Accompanied by Limphangiogenesis
The difficulty of creating a complete molecular characterization of uterine cervix cancer is the greatest problem in determining a proper course
of therapy in treating the disease. Little data are available about D2-40 expression in both lymphatic endothelial cells and tumor cells of uterine
cervix cancer. The aim of the present work was to study the involvement of lymphatics in the prognosis and tumor progression of the uterine
cervix lesions. We used D2-40 immunostaining to highlight lymphatic vessels from squamous cell metaplasia (n=17), cervical intraepithelial
neoplasia (n=11), carcinoma in situ (n=7), microinvasive carcinoma (n=10), and invasive carcinoma (n=49) using the avidin-biotin technique
(LSAB ). We found inconsistencies between the interpretation of the lymphovascular invasion of the routine haematoxylin-and-eosin-stained
cells and others observed immunohistochemically. Our results showed differences in the distribution and D2-40 expression in lymphatic vessels
and tumor cells from the cervix lesions linked to their histopathology and the grade of the tumor.
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Cuvinte-cheie uterine cervix cancer, lymphangiogenesis, immunohistochemistry |
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