Background: Monitoring of aggregate, ward-supply data and analysis of the anatomical therapeutic chemical_defined daily dose system, adjusted for bed-occupancy, provides a clear picture of antibiotics consumption frequency and time-trends within hospitals and especially intensive care departments. Material and methods: For this study we used data of a five-year (2010-2014) period, in therapeutic intensive care department of the Emergency Medicine Institute, which show the consumption dynamics of anti-infectives for systemic use of drugs in grams and value indexes. results: The defined daily doses (DDD) per 1000 occupied-bed days (DDD_OBD) of antibiotics in therapeutic intensive care department decreased from 1524 in 2010 to 1206 DDD_1000 in 2014 or by 20.87%, however, it is by 11.77% higher than medium consumption of 1052.25 DDD/1000 in intensive care units with the same activity in international hospitals. The value of 54948 lei per DDD_1000 OBD in 2010 recorded a decline to 40754 lei or by 25.84% in 2014. The cost of one medium DDD from 36.05 lei in 2010 decreased to 33.77 lei or by 6.33% in 2014. The average antibiotics annual institution consumption constituting 464.1 DDD_1000 in 2014 was higher by 1.06% comparatively with medium consumption of 459.20 DDD/1000 registered in 1706 international hospitals, and by 35.31% in comparison with global consumption of 343 defined daily doses per 1000 patient-days. conclusions: The decrease of DDD/1000 OBD and their cost took place as a result of efforts for rational use of antibiotics during the evaluated period. Great opportunities were found for improving rational utilization of anti-infectives for systemic use.