Background: The prognosis and severity of cranial trauma consequences are usually determined by primary cerebral damage and affect mental, physical human activity and quality of life. The indicator of quality of life should be considered when planning and evaluating the effectiveness of rehabilitation. The aim of the study was to assess the quality of life in patients with severe cranial trauma in distant period after the accident. Material and methods: in order to plan rationally rehabilitative measures, in 77 patients with severe cranial trauma in distant period, the main categories of life quality based on analysis of SF-36 questioner electronic data were investigated. Cognitive functions by means of МоСА-test and level of anxiety and depression (HADS) were studied as well. According to the duration of posttraumatic period all patients were divided into 4 groups. Results: Reliable difference was established between the values of scale SF-36 columns and normal standards. The role functioning connected with physical activity decreased with increasing of posttraumatic period. The lowest indexes of life quality and general health state were found in patients who had trauma 10 years ago. Some indexes of SF-36 scale were dependent on the level of anxiety, depression (scale of HADS) and the state of cognitive functions (scale MoCA). Conclusions: In distant period of severe cranial trauma all indexes of life quality according to the scale SF-36 were decreased due to its psychiatric component.