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SM ISO690:2012 MUSTEAŢĂ, Vasile, CORCIMARU, Ion, MUSTEAŢĂ, Larisa, ROBU, Maria, CHIU, Maria, BURUIANA, Sanda. Rezultatele nemijlocite aletratamentului leucemiei mieloide cronice cu imatinib mesilat
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2009, nr. 3(10), pp. 243-246. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(10) / 2009 / ISSN 1857-1719 | ||||||
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Pag. 243-246 | ||||||
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Imatinib Mesylate is an inhibitor of tyrosine kinase activity of chimeric BCR-ABL
gene, situated at chromosome 22, and has been considered as a “targeted therapy” in the
management of chronic myeloid leukemia . Complete hematologic response was achieved in
chronic and accelerated phases in 39 (90.6%) patients within 1 – 2 months of the therapy with Imatinib Mesylate. In patients with complete hematologic response the repeated cytogenetic
examination of the bone marrow revealed the decrease of myeloid cells bearing Phchromosome
up to 0 – 35%, that certified the major or complete cytogenetic remission. |
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