Introduction. Dust mites are the main source of indoor allergens, being important trigger of bronchial asthma and allergic rhinitis. Exposure to dust mites sources is an important cause of asthma exacerbations. A significant number of molecular components was described, the major allergens being Der p1/Der f1, Der p2/Der f2, Der p23, having the highest prevalence among indoor aeroallergens. The molecular component Der p10 is considered the minor allergen responsible for inducing cross-reactivity between mites and crustaceans, mollusks, insects and fish parasites - anasakis simplex. Objective of the study: to study the prevalence of cross-reactivity in asthmatic patients sensitized to house dust mites. Material and methods. The study group included 196 patients with bronchial asthma, aged between 8-18 years. According to the profile of molecular sensitization to allergens (Alex multiplex test), 73 patients (76%) are sensitized to house dust mites. In most patients, the major allergens Der p1, Der p2, Der p23, Der f1, Der f2 predominate. Sensitization to the Der p10-tropomyosin allergen was detected in 7 patients (9.58%) of the studied group, of which 4 patients (5.47%) were found to have cross-reactivity with Anisakis simplex fish worms Ani s3, crustaceans and mollusks: Pen m1, Chi spp, Hom g, Rud spp; insects Ten m, Loc m, Ach d, Per a7, Blo t10. Two patients reported reactions to the consumption of shrimps and some types of fish manifested by urticaria, oropharyngeal discomfort, lip edema and cough, two others reported suspicious reactions sometimes correlated with the consumption of crustaceans. Results and Conclusions. Dust mites represent the main source of indoor aeroallergens, the prevalence being 76% of the studied group. The prevalence of Der p10 was detected in 9.58% of which in 5.47% with the presence of cross-reactivity with crustaceans-molluscs. The patients’ symptoms with this type of sensitization is described as the mite-crustacean-mollusk syndrome. Early detection of patients with mite-crustacean-mollusc cross-reactivity is required by the severity of symptoms and the risk of anaphylactic reactions.