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SM ISO690:2012 YAVERI, A., GASANOVA, Ş., HOSSEINNEJAD, S.. Lipid peroxidation and antioxidant system parameters in diabetes mellitus type 2. In: Curierul Medical, 2012, nr. 6(330), pp. 40-42. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 6(330) / 2012 / ISSN 1875-0666 | ||||||
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Pag. 40-42 | ||||||
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Experimental and clinical observations proved the participation of reactive oxygen species (ROS) and initiated their lipid peroxidation (LPO) in the pathogenesis of many diseases, including diabetes mellitus. The studies were conducted with the blood of 57 patients with type 2 diabetes (male 21, female 36). All patients were divided into 3 groups based on the duration of the disease, as well as glucose levels: 1 year – compensation stage (n =
27); from 6 to 10 years – the stage subcompensation (n = 12); and more than 10 years – the stage of decompensation (n = 18). The amount of glucose was determined by the glucose oxidase method using ready commercial reagent. As a biochemical marker also was determined level of HBA1c. As a result conducted experiments was determined,that in all 3 stage of desease there is an increased level of LPO, also consentration of MDA, DC. LPO processes were quantitatively investigated using the spectrophotometric method, we determined serum levels of conjugated dynes – primary products
of lipid peroxidation and malondialdehyde (MDA) – one of the secondary products. Ferritin levels were determined using a commercial reagent for immunosorbent assay of human ferritin. There is noticeable changes in dates of AOS-decreases the level of reduced glutation,catalase,in contrary increases the level of ceruloplamin. In maximum grade there is incease in level of ferritin – 2.4 times. These dates prove that depending level of glucose in blood increase LPO and decreases AOS of organism. |
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