Introduction: Thanks to its high diagnostic performance, cardiac computed tomography with coronary CT angiography, also known as coronary computed tomography angiography (CCTA), has become one of the commonly used methods of investigation in cardiac pathology. In fact, it represents the only complete, non-invasive examination that assesses both the cardiac anatomy and the extent of coronary artery disease. Content: The presentation reviews several techniques available to us. Initially, an acquisition without injection of contrast medium will allow the calculation of the calcium score which has emerged as the most powerful predictor of coronary events in asymptomatic patients. At a second step, the injection of contrast medium will allow us to study in a precise way, the luminogram of the coronary arteries using different means of reconstruction. The technique has a negative predictive value over 90%, allowing to avoid performing coronary angiography for diagnostic purposes. However, despite its very rapid progress in recent years, the technique has many limitations. Most of these limitations are related to the patient’s status (weight, heart rate, arrhythmia, cooperation, etc), and can be minimized by patient selection in order to increase the benefit from the investigation. Secondly, we will have to have a «good condition of the patient» for the success of the examination. This involves adjusting the parameters related to the physiology of the patient, and those related to the employed technique and adapted protocols for image acquisition and reconstruction. Conclusions: The presentation provides a variety of explanations and solutions to the potential problems we may face when performing the investigation.