The study aimed to analyze the epidemiological situation regarding rabies in the Republic of Moldova from 2010 to 2022. The obtained results showed that in the Republic of Moldova rabies evolves endemic, and the annual number of rabies cases in animals has dragging variations with value reaching incidences from 58 cases (2011) to 167 cases (2015), is characterized by successive waves of increasing the number of sick animals with a periodicity of 2 to 3 years. The presented data also showed a correlation between the increase in the number of rabies cases in domestic animals in accordance with the number of cases of rabies in wildlife (in foxes). The highest share of rabies in animals was recorded in foxes; these animals are considered the main factor in the spread of the disease. At the same time, the wildlife vaccination program (2020-2022) through the administration of baits from the plane, has contributed to reducing the number of rabies cases considerably in wildlife and domestically animals and the immunological efficiency of the vaccinated foxes was the presence of antibody titers in more than 50% of the shouted exanimated foxes.