Patients with bronchiectasis, very often, may present an impaired lung function (obstructive/restrictive ventilator pattern) and deteriorated health-related quality of life (HRQL). Aim of the study was to determine the HRQL and lung function features in patients with bronchiectasis according to their etiology and radiological severity. We performed a cross-sectional study on 109 patients with bronchiectasis confirmed by HRCT, admitted to a tertiary level hospital in Republic of Moldova between years 2016-2018. Etiologically, patients were divided into three groups: idiopathic, COPD associated and postinfectious bronchiectasis. All of the patients had undergone lung function investigation, and completed the Quality of Life Questionnaire-Bronchiectasis (QOL-B). Based on imaging data, a modified Reiff (mReiff) score was calculated. We have analyzed 109 consecutive patients with idiopathic (40 patients, 37%), COPD associated (25 patients, 23%) and postinfectious bronchiectasis (44 patients, 15%), with the mean age 58,32 ± 12,45 years, 65% (n=70) were males, 51% (n=55) were current/ex-smokers. Normal FEV1 was found in 22% (n=24) of cases. FEV1˂50% was registered in 54% (n=59), and 23% (n=25) had severe obstruction (FEV1˂30%). Median value of FEV1 (%) was significantly decreased in those with COPD associated bronchiectasis (35; [25-42]) compared to idiopathic (48,4; [29,5-80,5], p=0,003) and postinfectiou bronchiectasis (55,4; [37,4-81,7], p˂0,001). The worst mReiff score (˃12 points) was determined in 12% (n=13) of cases, while the majority of the patients (59%, n=64) have got less than 6 points. Analyzing the severity of bronchiectasis on the chest HRCT according to their etiology, it was established that a higher mReiff score was found in the idiopathic bronchiectasis group (9,5; [5,5-12]) compared to postinfectious (5; [2-7], p˂0,001) and COPD associated (4; [3-5], p=0,001). No statistically significant difference of HRQL was registered according to bronchiectasis etiology. The lowest score was determined for the Physical Scale of QOL-B (20; [0-40]). Our study suggests that in patients with non-cystic fibrosis bronchiectasis, abnormal changes in pulmonary function depend on the underlying disease and, to a lesser degree, on the HRCT score. Patients with COPD associated bronchiectasis exhibited lower values of FEV1, but radiologically these bronchiectasis tend to be less impressive. HRQOL in patients with bronchiectasis doesn’t depend on their etiology.