Introduction. Percutaneous nephrolithotomy (PCNL) is a minimally invasive procedure to remove kidney stones by a punction through the skin in lumbar region. This procedure is accepted as standard of care for patients with kidney stones that are large and resistant to other forms of urolithiasis. Objective. Stone free rate obtained in the clinic following PCNL intervention applied to patients with urolithiasis, during 4 years (20192023). Material and methods. The study was performed in the Department of urology and surgical nephrology of the State University of Medicine and Pharmacy «Nicolae Testemițanu», on a group of 175 patients with diagnosis of urolithiasis. Results. Anatomical distribution of renal stones: right kidney 81(46,3%) patients, left kidney 94(53,7%) patients. The stones size ranged from 2 cm up to massive staghorn stones (>4,5cm). The after-surgery hospitalization period on average was 4,5 days. Four patients had solitary kidney. From the group of study, 5 (2,9%) of them were tubeless, 4 (2,3%) were with two puncture channels, and 1 (0,6%) patient was with three puncture channels. The stratification of the surgical after surgery complications was evaluated according to the Clavien-Dindo score. CDS I: 145(82,85%); patients CDS II: 26(14,85%) patients, CDS III: 4 (2,3%) patients. Patients with CDS IV and V were not detected. Conclusions. The success of PCNL is dependent on many factors such as stone composition, stone size, number of stones, localization, body mass index. The stone free rate was 91% and 100% following by “second look” procedure: ESWL, Ureteroscopy.