Introduction. Renal tumors are on the 4th place in the structure of malignant diseases in children, constituting between 5.5–7.0%. Nephroblastoma (Wilms Tumor) has the highest frequency, accounting for 500 children per year, according to reports from the United States. Material and methods. The study was carried out on a group of 11 patients with renal tumors treated in the Institute of Mother and Child, the National Scientific-Practical Center of Pediatric Surgery “Natalia Gheorghiu”, the Urology Department and the PHI Oncological Institute, the Oncopediatric Department. Results. The diagnosis of renal tumor was established in 11 patients aged 2 -10 years. At the clinical examination, the common signs were: palidity and gray tint of the skin, asymmetry of the abdomen, enlargement in the hypochondrium and the respective flank - tumor formation with lumbar contact. Pronounced vascular drawing on the abdominal wall with the appearance of venous stasis was determined in 9 patients. In all cases, renal ultrasound showed impressive dimensions from 4.8 x 5.2 to 9.5 x 8.4 x 7.9 with deformation and asymmetry of the flank of the abdomen. Computed tomography and magnetic resonance confirmed the clinical diagnosis. In 6 patients, the tumor was of large size requiring primary polychemotherapy, subsequently surgical. The histopathological examination detected the presence of nephroblastoma in 10 children, in 1 child - angiomyolipoma. Conclusions. Multidisciplinary approach in order to establish correct management, can ensure an increased rate of healing in children, with the prevention of the dissemination and metastasis of renal neoplasm.