Modern conditions of the external environment imply significant changes in the activities of companies. The changes are so significant that they are called the Fourth Industrial Revolution. Thus, the cardinality of changes is caused by the introduction of new technologies, which, on the one hand, significantly increase the efficiency of the enterprise, but on the other hand, carry many risks. Thus, the forthcoming changes in the enterprises of the Republic of Moldova are accompanied by resistance on the part of the personnel. The aim of the work is to identify the main causes of resistance to organizational change under the conditions of Industrialization 4.0, to diagnose the causes of resistance in Moldovan enterprises, and to develop recommendations for reducing resistance.