Actuality. Myopia is labeled as one of the most common eye disorders, with a high incidence and prevalence worldwide. Currently, according to the literature, one of the most effective methods of treatment and stopping the progression of myopia is orthokeratological treatment. Anisometropic amblyopia was clinically identified in 1743 by George Louis Leclerc, Count of Buffon, who proposed a treatment applied even in the present. Anisometropic amblyopia continues to be treated by optical correction applied separately or in combination with occlusion or other therapies. Aim: Assessment of myopia progression in patients with anisometropic amblyopia who have undergone orthokeratological treatment combined with visual therapy. Methods. Clinical cases were divided into four groups of 16 eyes depending on the degree of myopia (small or medium) and the presence or absence of amblyopia. Results. The application of the combined treatment for 3 years resulted in the cessation of myopia according to the spheroequivalent from 0.94 D to 0.28 D in patients with amblyopia and mild myopia and from 0.93 D to 0.06 in those without amblyopia . The values of the antero-posterior axis had a similar dynamics, the differences being statistically significant (p <0.001). In patients with moderate myopia its evolution had a similar dynamic, but more significant in patients without amblyopia: from 1.54 D to 0.06 D compared to patients with amblyopia - from 1.38 D to 0.28 D. After 3 years of study, the degree of anisometropia decreased from 3.43 D to 3.18 D (p> 0.05), the correlation between the annual gradient of progression of myopia and the degree of anisometropia being direct (R² = 0.8846 ). Corrected visual acuity depending on the degree of amblyopia had a positive dynamic as well: from 0.63 to 0.97 in cases with mild amblyopia and from 0.26 to 0.72 in cases with moderate amblyopia, the statistical difference between groups being highly true (p <0.001). The absolute volume of accommodation had comparative dynamics and increased from 7.0 to 12.0 in patients with mild amblyopia and from 2.2 to 9.5 in patients with moderate amblyopia. The statistical differences between the results were highly true (p <0.001). Conclusions. It is rational to apply refractive therapy in the treatment and prevention of the progression of mild and moderate acquired uncomplicated myopia, with an average index of quality of life of 93.1%, versus 39.3% for optical correction.