The European Commission (EC) stresses that “transition to a more circular economy requires changes throughout value chains, from product design to new business and market models, from new ways of turning waste into resource to new models of consumer behaviour” (COM 0398 final, 2014). Industrial Symbiosis (IS) has been highlighted as a strong pathway to implement a circular economy, by developing waste-as-resource business models aiming at using industrial waste as secondary resources and promote cross-sector and cross-cycle collaborations by creating markets for such secondary raw materials (European Environment Agency, 2016). This approach moves towards a more sustainable and integrated industrial system that will contribute to solving the developmental and environmental challenges articulated in the Sustainable Development Goals (SDGs 6, 7, 8, 9, 12 and 13). While the potential of industrial symbiosis (IS) to achieve green growth and implement the circular economy has been demonstrated, IS development is still hampered by environmental (e.g., national, and international constraints, low taxes for disposal, etc.), economic (e.g., lower price of raw materials compared to industrial by-products produced, low transportation costs), technical, regulatory/legal, organisational, social and cultural barriers. This paper describes the methodology that will be implemented through LIAISE COST Action proposal in order to overcome the challenge of being the first EU and international wide network to create a common framework in terms of IS for different actors (academics, researchers, industrials, policymakers, user’s representatives, etc.) for the years to come.