Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
81 0 |
SM ISO690:2012 BRANDL, Michael, CEBAN, Alexei, SAJIN, Octavian, BUCOV, Victoria, CATARAGA, Alina, STRATULAT, Silvia, FURTUNA, Nicolae, GUŢU, Veaceslav, GHEORGHIŢA, Stela, GASSOWSKI, Martyna, MOȘINA, Liudmila, MOZALEVSKIS, Antons, DUDAREVA, Sandra, DATTA, Siddhartha Sankar. Evaluating the hepatitis B vaccination impact in the Republic of Moldova: A nationwide representative serosurvey of children born in 2013. In: IJID Regions, 2024, vol. 10, pp. 60-66. ISSN 2772-7076. DOI: https://doi.org/10.1016/j.ijregi.2023.11.003 |
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IJID Regions | |
Volumul 10 / 2024 / ISSN 2772-7076 | |
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DOI:https://doi.org/10.1016/j.ijregi.2023.11.003 | |
Pag. 60-66 | |
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Rezumat | |
Objectives: The WHO European Region set targets for the control of hepatitis B through immunization, including prevalence of hepatitis B surface antigen (HBsAg) at ≤0.5% in vaccinated cohorts. The Republic of Moldova implemented universal hepatitis B vaccination since 1995. We conducted a nationwide representative serosurvey to estimate HBsAg seroprevalence in children born in 2013 to validate hepatitis B control targets. Methods: We used probability-based sampling and a two-stage cluster design. All children born in 2013 and registered in primary healthcare facilities were eligible for participation. We tested blood samples of all participants for hepatitis B core antibody (anti-HBc), using Enzyme-Linked Immunosorbent Assay (ELISA). Anti-HBc-positive samples were tested for HBsAg and HBsAg-positive samples confirmed, using ELISA. We obtained information on hepatitis B vaccination from vaccination cards. Results: Of 3352 sampled children, 3064 (91%) participated. Most participating children were 7 years old (n = 3030, 99%), 1426 (48%) were girls. The weighted, national seroprevalence estimate was 3.1% (95% confidence interval = 2.1-4.5) for anti-HBc and 0.21% (95% confidence interval = 0.08-0.53) for HBsAg. Conclusion: The study demonstrated the impact of hepatitis B vaccination and allowed the Republic of Moldova to validate regional hepatitis B control targets. Other countries with high vaccination coverage could use hepatitis B serosurveys and apply for validation. Sustained efforts in the Republic of Moldova will be crucial on the path to hepatitis B elimination. |
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Cuvinte-cheie Europe, hepatitis B, prevalence, Republic of Moldova, Seroepidemiologic study, vaccination |
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