Introduction: The bibliographic data report the effectiveness of estradiol as adjunctive treatment in women suffering from schizophrenia. It is reported that the adjuvant treatment with estradiol would require low doses of neuroleptics to obtain the therapeutic effect. Several studies starting since 2012 (Kulkarni, 2012) till 2019 (Weiser et al., 2019) come in with similar results. Methods: A randomized, double-blind study was conducted in which patients have taken transdermal patches with 200μg estradiol. The age of inclusion was between 38 and 45 years. Affective parameters were analyzed in 50 patients (25 estradiol and 25 placebo). The duration of the study was 16 weeks. Results and discussions: The following affective parameters from PANSS scale were assessed: blunted affect, emotional withdrawal, poor rapport, anxiety. Conclusions: No significant differences were found in both patient groups at the beginning and the end of the study.