Introducere. Pacienții cu cancer de prostată localizat sunt electivi pentru intervenție chirurgicală, radioterapie sau supraveghere activă. În Republica Moldova principala metodă de intervenție chirurgicală este prostatectomia retropubiană deschisă. Scopul lucrării. evaluarea eficacității prostatectomiei retropubiene deschise și studierea rezultatelor postoperatorii pe termen scurt și lung la pacienții cu cancer de prostată localizat. Materiale și metode. În perioada iunie 2021 – februarie 2023, în secția urologie a Spitalul Clinic Republican „Timofei Moșneaga” s-au efectuat 20 de prostatectomii retropubiene deschise la pacienții cu CP localizat. Riscul scăzut de recidivă biochimică conform D’amico, cât și riscul intermediar a fost identic întâlnit în 8 cazuri ambele, iar riscul înalt s-a stabilit în 4 cazuri. Rezultate. Vârsta medie a pacienților a fost de 67,3 ani. Nivelul mediu PSA preoperator la pacienți a fost de 12 ng/ml. Limfodisecția pelvină extinsă a precedat prostatectomia efectuată la 9 pacienți (45% cazuri). Printre complicațiile intraoperatorii, s-a enumerat hemoragia din plexul venos Santorini în 3 cazuri. Hemostaza a fost obținută prin suturarea plexului venos dorsal și tamponarea spațiului retropubian. În perioada postoperatorie, un pacient a prezentat limforee prelungită. Numărul mediu a zilelor de spitalizare a fost de 8 zile (3-25). Îndepărtarea cateterului uretral s-a efectuat la 3-4 săptămâni postoperator. Continența urinară a fost restabilită la majoritatea pacienților în decurs de 6 luni. Concluzii. Prostatectomia retropubiană deschisă este o metodă chirurgicală eficientă pentru tratamentul cancerului de prostată localizat, cu un nivel scăzut de complicații postoperatorii.

Background. Patients with localized prostate cancer are candidates for surgery, radiation therapy, or active surveillance. Open retropubic prostatectomy (ORP) is the most common surgical treatment in the Republic of Moldova. Objective of the study was to evaluate the effectiveness of ORP and to study early and long-term postoperative outcomes in patients with localized prostate cancer. Material and methods. In the period from June 2021 to February 2023, ORP was performed in 20 patients with localized prostate cancer at the Urology Department of the Timofei Moșneaga Republican Clinical Hospital In 8 patients was determined a low risk of biochemical recurrence, in 8 patients was established intermediate risk and in 4 patients high risk of biochemical recurrence. Results. The mean age of the patients was 67.3 years. The mean preoperative PSA was 12 ng/ml. Extended pelvic lymphadenectomy preceded prostatectomy in 9 patients (45%). Among the intraoperative complications, there was bleeding from the veins of the Santorini plexus in 3 cases. In the postoperative period, one patient had prolonged lymphorrhea. The median number of days a patient spent in hospital after surgery was 8 days (3-25). Removal of the urethral catheter was performed on the 3-4th week. Urinary continence was restored in patients within six months after surgery. Conclusion. Open retropubic prostatectomy is an effective surgical method for treatment of clinically localized prostate cancer with low level of postoperative complications.

Background. Patients with localized prostate cancer are candidates for surgery, radiation therapy, or active surveillance. Open retropubic prostatectomy (ORP) is the most common surgical treatment in the Republic of Moldova. Objective of the study was to evaluate the effectiveness of ORP and to study early and long-term postoperative outcomes in patients with localized prostate cancer. Material and methods. In the period from June 2021 to February 2023, ORP was performed in 20 patients with localized prostate cancer at the Urology Department of the Timofei Moșneaga Republican Clinical Hospital In 8 patients was determined a low risk of biochemical recurrence, in 8 patients was established intermediate risk and in 4 patients high risk of biochemical recurrence. Results. The mean age of the patients was 67.3 years. The mean preoperative PSA was 12 ng/ml. Extended pelvic lymphadenectomy preceded prostatectomy in 9 patients (45%). Among the intraoperative complications, there was bleeding from the veins of the Santorini plexus in 3 cases. In the postoperative period, one patient had prolonged lymphorrhea. The median number of days a patient spent in hospital after surgery was 8 days (3-25). Removal of the urethral catheter was performed on the 3-4th week. Urinary continence was restored in patients within six months after surgery. Conclusion. Open retropubic prostatectomy is an effective surgical method for treatment of clinically localized prostate cancer with low level of postoperative complications.