Introduction. With the implementation of safety regulations in the COVID-19 pandemic, there have been major disruptions in the care of patients with colorectal cancer (CRC). Background. Analysis of the impact of the COVID-19 pandemic on patients with CRC. Methods and material. Retrospective study on 376 patients treated in Emergency Hospital (Chisinau) during 2018-2021. Ratio M:W=1:1, mean age – 65.41±0.55 years. Patients were divided into 2 groups: I group (control) – 219(58.25%), (2018-2019), II group (pandemic) – 157(41.76%), (2020-2021). Demographic, clinical, intraoperative, pathological data and mortality were evaluated comparatively. Results. There was a 28.31% reduction in hospitalizations for CRC in the pandemic group (p<0.01). If the rate of emergency hospitalizations and the type of CRC complications were identical in both groups, then the derivative procedures (colo/ileostomy) were higher in the pandemic group, 71(45.22%) vs 60(27.40%), (p<0.05). The advanced stages of the disease were recorded during the restrictions. Although the age indicators were not different, comorbidities were more common for patients in the pandemic group (p<0.05), 14.02% also endured SARS-Cov-2 infection until hospitalization, and 11(7.01%) were dignosed with COVID-19 during hospitalization for CRC, and mortality being significantly higher in the pandemic group – 20.38% vs 14.16%, (p<0.05). Conclusion. The COVID-19 pandemic has had a major impact on the care of colorectal cancer patients. The results of the more unfavorable clinical and pathological findings are still unknown, but extensive multicenter studies are needed in this area, which would lead to future the management of surgical pathologies, including CRC.