Introduction. Patients with chronic diseases were lack of clinical management in the period of COVID-19 pandemic due to strict limitations. The aim of the study was to determine the burden of COVID-19 limitations on patients with SLE with different disease duration in the Republic of Moldova. Material and methods. Two groups of SLE patients were examined by the activity of the disease (Patient Global Assessment, PGA) and Lupus Impact Tracker (LIT). The first group - 34 patients with a disease duration ≤ 2 years from diagnosis, and the second group – 67 patients with a disease duration > 2 years. Examinations were performed during the period of 01.04.2019 – 31.03.2020, by on-site visit, and 01.09.2020 – 01.09.2021 by phone. Results. Data showed the increase of PGA in both groups, (I group: 47.9 at the first visit and 54.3 at the second visit; II group: 46.3 to 48.2 points) more significantly in patients with shorter disease duration. The disease impact on lupus patients was increased in both patient groups. I group showed an increase of the score from 50.0 to 62.5 (median), r=0.92, p<0.0001. In the II group, the median LIT value did not increase (47.5), but the correlation of values at different visits was found, and the tendency to values increase was observed, r=0.87, p<0.0001. Anxiety, depression, and difficulty concentrating had an impact on patients (LIT increasing), mostly those with shorter disease duration. Conclusion. The increased burden of the disease during the COVID-19 pandemic according to LIT, markedly on lupus patients with shorter disease duration was determined by considerable psychological symptoms.