Introduction. People who smoke are vulnerable to lung infections caused by a wide range of pathogens. The increased susceptibility to respiratory infections is explained both by the effect of cigarette smoke components on the airway epithelium, but also by the immunological changes in both cell-mediated and humoral immunity. Objective of the study. The presentation of clinical, imaging, bacteriological aspects on smoking patients with pneumonia. Material and methods. The clinical, paraclinical and imaging data of 74 patients hospitalized with communityacquired pneumonia, 53 of which are smokers and 21 - non-smokers. Results. The average age was 57 years (18-84 years). According to the CURB65 score, we found that community-acquired pneumonia with moderate and severe evolution prevailed on smokers, constituting 71.7% of cases, while on non-smokers prevailed pneumonia with mild evolution - 57.2% of cases. The radiological examination revealed the bilateral localization of the infiltrative process on 41.5% smoking patients, versus 33.3% on non-smokers. The cause of pneumonia on smokers was confirmed in 61.4% of cases, and on non-smokers in 52.4% of cases. The staphylococcal infection was present in 13.3% of smokers, versus 4.8% of non-smokers (P˂0.05). Conclusions. Pneumonia at smokers evolved with a higher degree of severity and bilateral localization. The broad etiological spectrum included bacteria that had a lower share on non-smokers.