Introduction. Antibiotic consumption is increasing worldwide, especially in low- and middle-income countries. Studies have shown that the choice of antibiotic or its duration is incorrect in 25% to 75% of cases. Optimizing the use of antibiotics is critical to effectively treat infections, protect patients from harms caused by unnecessary antibiotic use, and prevent antibiotic resistance. Material and Methods. Statistical data, results of centralized public procurement for 64 public health institutions in the Republic of Moldova, for the years 2018-2021, according to the Center for Centralized Public Procurement in Healthcare, using the defined daily dose (DDD) as the unit of measurement recommended by the World Health Organization for drug utilization studies. Results. As a result of the systematization of the antibiotic consumption data for 4 years, an increase of the following groups of antibiotics is shown: for 2018 (Cephalosporins and Imidazole derivatives), for 2019 (Carbapenems, Glycopeptides, Nitrofuran derivatives, Beta-lactam antibiotics, Penicillins), for 2020 (Macrolides, Cephalosporins, Tetracyclines), for 2021 (Fluoroquinolones, Lincosamides) etc, the data obtained are expressed in DDD/1000 hospital days. Conclusion. This study reflects the fact that it is necessary to create and introduce an antimicrobial stewardship program in hospitals and continue to monitor antibiotic consumption, prescribing habits and antibiotic resistance.