Introduction. The most common and serious symptom experienced by patients requiring palliative care (PC) is pain. Adequate and barrierfree access to opioid medication for medical purposes and the availability of medication in inpatient and outpatient settings have a major impact on patients' quality of life. Material and methods. The analysis of treatment schemes, the consumption of opioid drugs, the pharmaceutical assistance of patients in the PC process and the evaluation of the influencing factors of this process in inpatient and outpatient conditions. Results. A methodology was developed to estimate the need for opioid analgesic drugs and the plan of pharmaceutical assistance with them for patients who require PC in inpatient and outpatient conditions. Various methods were proposed for calculating the consumption coefficient for each drug in this group based on the average number of bed-days (inpatient) or the number of patients planned for treatment (outpatient) and the maximum dose of drugs for one day. For additional outpatient conditions, the average number of days of administration was taken into account. Methodical recommendations were developed regarding the practical application of calculation methods. The methodology was approved and recommended for use in medical practice by order of the Ministry of Health of the Republic of Moldova no. 268 of 31.03.2017. Conclusions. The methodology for calculating the need for opioid analgesics and pharmaceutical assistance for patients undergoing PE treatment in inpatient and outpatient conditions was developed, which proved to be accessible, efficient, truthful and easy to implement.