Occult hepatitis B infection associated with chronic viral hepatitis C in a young child
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RABA, Tatiana, LIUBARSCAIA, Svetlana. Occult hepatitis B infection associated with chronic viral hepatitis C in a young child. In: Perspectives of the Balkan medicine in the post COVID-19 era: The 37th Balkan Medical Week. The 8th congress on urology, dialysis and kidney transplant from the Republic of Moldova “New Horizons in Urology”, Ed. 37, 7-9 iunie 2023, Chişinău. București: Balkan Medical Union, 2023, Ediția 37, p. 256. ISSN Print: ISSN 1584-9244 ISSN-L 1584-9244 Online: ISSN 2558-815X.
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Perspectives of the Balkan medicine in the post COVID-19 era
Ediția 37, 2023
Congresul "Perspectives of the Balkan medicine in the post COVID-19 era"
37, Chişinău, Moldova, 7-9 iunie 2023

Occult hepatitis B infection associated with chronic viral hepatitis C in a young child


Pag. 256-256

Raba Tatiana, Liubarscaia Svetlana
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 5 ianuarie 2024


Rezumat

Introduction. The association of occult hepatitis B infection (OBI) and chronic viral hepatitis C (HVCC) has a worldwide prevalence of 1-15%, being another underestimated one in children. Material and methods. The data of a patient diagnosed with OBI associated with HVCC with minimal HCV viremia, based on the outpatient medical record F112/e, are presented. Results. Boy aged 2 years, 10 months, diagnosed with HVCC at the age of 2 years and referred to a pediatric gastroenterologist for consideration of antiviral treatment. The child's mother is under surveillance with chronic HBV infection for more than 3 years. At birth, the child was vaccinated in the first 24 hours with anti-HVB1 with the concomitant administration of anti-HVB-specific immunoglobulin Ig, followed by 3 doses of antiHVB vaccines. At the age of 5 months, the child underwent surgery for capillary-cavernous hemangioma at the base of the scrotum. The immunoserological examination of the child at the age of 2 showed cytolysis of the first degree with an increase of ALT and AST 2 times compared to the reference values, HBsAg (-), anti-HBcor summary (+), anti-HBcor IgM (-), anti-HBs (+), HBe Ag (-), anti-HBe (-), negative quantitative HBV DNA, summary anti-HCV (+), positive HCV RNA 409 367 IU/ml. The diagnosis of OBI seropositive form ("occult" phase) and HVCC genotype 1b with minimal viremia was established, being eligible for antiviral treatment. Conclusions. The concurrent evolution of HBV and HCV infection in children requires complex evaluation with the determination of the priority viremia induced by the 2 viruses and the correct selection of the antiviral treatment scheme.