Introduction. The instability of the wrist joint leads to deforming osteoarthritis, painful and limited range of motions, decreased strength and impaired hand function. There are some surgical options, one of them is arthrodesis, when by losing the amplitude of movements we can achieve a stable wrist, without pain and to restore gripping power. Material and methods. Our experience is based on the treatment of 146 patients with wrist instabilities of different etiology aged between 17 and 70 years who underwent various selective arthrodesis. Kienbock disease was diagnosed in 47 patients, pseudoarthrosis of the scaphoid complicated by deforming osteoarthritis in 75 cases, 10 rotational subluxation of the scaphoid, 6 trapezium-trapezoid-scaphoid osteoarthritis and 8 malunion of the distal radius fracture. Results. In total was performed the following surgeries: 51 lunate-capitate-triquetrum-hamate arthrodesis, 32 scapho-trapezium-trapezoid, 18 Graner procedure, 13 total wrist arthrodesis, 9 capitate-scaphoid, 5 scapho-capitate, 5 radial-semilunar, 5 removing of the first row of carpal bones, 5 scaphoidectomy, and 3 radial-scaphoid. Long-term results were followed up in 53 patients: good (20), satisfactory (27). Unsatisfactory outcomes were in 6 cases because of absence of the ankylosis and presence of the pain. Conclusions. Selective wrist arthrodesis is indicated in deforming osteoarthritis grade II or III, when outstanding amplitude movements are up to 50% of normal range. Each case of wrist arthrodesis is chosen individually according etiology and patient activity.