Purpose. To evaluate the ocular tissue reaction to implanted antiglaucoma shunt with valve in rabbits. Methods. The newly designed antiglaucoma shunt from PMMA which has inside a silicone valve was tested in a preclinical study. The studied group consisted of 5 New Zealand White rabbits in which was induced ocular hypertension. The PMMA antiglaucoma device was implanted unilaterally and observed for 3 months. The follow up was performed by a certified ophthalmologist using slit-lamp biomicroscopy. The histological evaluation was compared with a control group without any surgery treatment. It was performed in both groups the hematoxylin and eosin, and trichrome staining. Results. The PMMA device caused a fibrotic capsule in the ocular tissue, and there were more fibroblasts in the study group than in the control group. There were no inflammatory cells in the samples (such as macrophages and lymphocytes). In all of the cases analyzed, the lumen of the antiglaucoma shunt with valve was devoid of inflammatory exudates or other impediments. Group A did not experience any negative effects for up to 90 days. Conclusion. The results of the histopathologic examination show that the antiglaucoma shunt with valve is safe and well tolerated, with no inflammatory reaction or detrimental consequences.