Validation of the impact of conventional prognostic scores in non-Hodgkin's lymphomas with nodal involvement
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TOMACINSCHII, Victor. Validation of the impact of conventional prognostic scores in non-Hodgkin's lymphomas with nodal involvement. In: Perspectives of the Balkan medicine in the post COVID-19 era: The 37th Balkan Medical Week. The 8th congress on urology, dialysis and kidney transplant from the Republic of Moldova “New Horizons in Urology”, Ed. 37, 7-9 iunie 2023, Chişinău. București: Balkan Medical Union, 2023, Ediția 37, p. 193. ISSN Print: ISSN 1584-9244 ISSN-L 1584-9244 Online: ISSN 2558-815X.
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Perspectives of the Balkan medicine in the post COVID-19 era
Ediția 37, 2023
Congresul "Perspectives of the Balkan medicine in the post COVID-19 era"
37, Chişinău, Moldova, 7-9 iunie 2023

Validation of the impact of conventional prognostic scores in non-Hodgkin's lymphomas with nodal involvement


Pag. 193-193

Tomacinschii Victor
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 26 decembrie 2023


Rezumat

Introduction. Non-Hodgkin lymphomas (NHL) represent a heterogeneous group of malignant lymphomas that develop from the malignant proliferation of the lymphatic tissue. Different prognostic scores (PS) are proposed to be used to determine NHL prognosis. The present study aims to estimate the utility of conventional PS for the determination of NHL overall survival (OS). Material and methods. 78 patients diagnosed with nodal NHL have been evaluated. International Prognostic Index (IPI), The combined index of hemoglobin, albumin, lymphocyte, and platelet (HALP), Platelet to Lymphocyte Ratio (PLR), Neutrophil to Lymphocyte Ratio (NLR), albumin/ globulin ratio(A/G), Charlson comorbidity index (CCI), were calculated as in the original references. Results. Out of the patients enrolled in the study, 67 developed B cell NHLs and 11 T cell NHLs. The mean age of the patients was 58(range 2283 years); The most frequent area of primary lymph node(ln) involvement was peripheral ln (84.61%), mediastinal ln (10.25%), and abdominal ln (5.12%); Aggressive NHLs were diagnosed in 73.07% of patients and indolent NHL in 26.93%; By using ROC analysis it was determined that the most sensitive score for determining OS was IPI (AUC=0.745), followed by HALP (AUC=0.652), PLR (AUC=0.625); NLR (AUC= 0.605); CCI (AUC=0.635); A/G (AUC=0.588). Conclusions. Among the evaluated prognostic tests, the IPI score and the HALP score proved to be the most sensitive results in the prognostication of the OS of NHL patients.