Introduction. Preterm birth is the leading cause of neonatal morbidity and mortality and is one of the major challenges of modern obstetrics and still lacks an efficient treatment. Although the underlying causes of pregnancy-associated complication are numerous, it is well established that infection and inflammation represent a highly significant risk factor in preterm birth. In fact, a sophisticated interaction occurs between contractile and immuno-inflammatory pathways, whereby proinflammatory amplification is intensified by collaborative connections between cells, ligands, and tissues. However, despite the clinical and public health significance, infectious agents, molecular trigger(s), and immune pathways underlying the pathogenesis of preterm birth remain underdefined and represent a major gap in knowledge. Objective. To estimate the comparative value of the serum levels of -Macroglobuline and prinflammatory citokins as a Interleukine-6. Methods. The study comprised 65 women with spontaneous preterm labor and 65 women with term labor. Maternal plasma concentrations of -Macroglobuline and Interleukine-6 were detected by standard test system Enzyme-like Immunosorbent Assay Kit for -Macroglobuline and Best-Vector A-8768 for Interleukine-6 Ref 3307 which (GmbH Co, Germany) gave an analytical sensitive of 0,35ng/ ml U/ml for -Macroglobuline and 0.131 pg/ml for Interleukine-6. The numerical values of the parameters were numbered in Excel table, after which – imported into the statistical analysis software R studio, using descriptive, variation, and correlational analysis. Applied statistic tests: nonparametrical Mann-Whitney test and p Spearman test were used as appropriate. P values less than 0.05 were considered statistically significant. Results. The results of this study demonstrated increase plasmal levels of the -Macroglobuline (min. 5.06 pg/ml, max. 99.88 pg/ml, μmedian = 46.97 pg/ml) in the women with preterm comparated to the control group, women with term delivery (min. 0.76 pg/ml, max. 80.84 pg/ml, μmedian = 1.10 pg/ml) (p0.001). At the same time, the study found a increase plasmal levels of the Interleukine-6 (min. 0.99 pg/ml, max. 192.93 pg/ml, μmedian = 51.90 pg/ml) in the women with preterm comparated to the control group, women with term delivery min. (9.65 pg/ml, max. 137.97 pg/ml, μmedian =21.51 pg/ ml) (p0.001). Conclusion. The study findings suggest that plasma levels of the -Macroglobuline and Interleukine-6 in women with preterm labor may be considered as a promising early biomarker for preterm labor.