Introduction. The relationship between the immune system and non-Hodgkin lymphomas (NHL) is complex. Immune complications can be assessed: before NHL, with lymphoma diagnosis, and later after treatment. Material and methods. The study included 62 NHL's patients with immune component (IC), average age 62.3±3 years, women-43 (69%), men-19 (31%), treated within the Hematology Center, Republic of Moldova (20202021). The association was analyzed according to NHL type, oncet and period of association. Results. The IC: indolent NHL 33 (58%), aggressive NHL 29 (42%) patients. Regardless of the type of NHL, immune hemolytic anemias (IHA) (31.1% and 22%), immune thrombocytopenias (IT) (12.9% and 3.8%) and immune thyroiditis (10.3% and 2.6%) prevailed. SLE independent of the NHL type was present with the same frequency (1.3%). Vasculitis, vitiligo-only in the indolent NHL, but psoriasis only in the aggressive NHL. In 82.8% of cases the association of 1 IC was appreciated, and in 17.2% multiple associations. The IC was appreciated in nodal (51.6%) and extranodal (48.4%) onset NHL, such as: spleen 23 (35.9%), thyroid gland and soft tissues (3.1% each), nasopharynx, skin, stomach and vertebra in only 1.5% each. IC developed during the NHL predominated (67.5%): IHA51.9%, IT-14.2%, autoimmune thyroiditis 1.3%. SLE, vasculitis, psoriasis, RA, vitiligo developed until NHL. Conclusions. A predominance of the immune component was demonstrated in indolent NHL with nodal, spleen onset, which developed more frequently during the disease, being predominantly manifested by IHA, IT and autoimmune thyroiditis. SLE, vasculitis, psoriasis, RA, vitiligo developed only until the diagnosis of NHL was confirmed.