Introduction. Currently, malaria continues to be a pathology with a major impact worldwide due to the intense migration of the population. Methods. A retrospective and prospective study was conducted on malaria cases, hospitalized in the "Toma Ciorbă" Clinical Hospital for Infectious Diseases in the last 5 years. Results. Over the last 5 years, 14 cases of imported malaria were registered in the Republic of Moldova: in 2018 – 1 case, in 2019 – 3, in 2021 – 3, in 2022 – 7. Of the 14 patients, 3 were with Pl.ovale, and 11 with Pl. Falciparum. Malaria patients contacted the disease in West and South Africa. Only 4 recieved chemoprophylaxis, and developed the medium form of disease. Patients requested medical assistance on average at 5.57±0.91 days with symptoms: fever 38°-40°C, chills, sweating, asthenia, muscle pain. Parasitological examination revealed the presence of parasitemia with Pl. falciparum between 720 and 1,520,000/mkl of blood. The evolution of the disease was medium in 6 patients, and in 8 patients - severe. Clinical examination revealed: hepatomegaly in 8 patients, splenomegaly in 4, pneumonia in 6 and 2 patients - cerebral edema, accompanied by polyorganic failure, which death. The biological tests: hypertransaminasemia – 8 patients, anemia - 2, thrombocytopenia - 11. The treatment consisted of combined antimalarials. The average duration of hospitalization was 6 days. Recurrences of malaria were determined in 5 patients. Conclusion. Chemoprophylaxis is important to prevent severe forms and the precocity of treatment determines the evolution of disease; the frequency of relapses is relatively high.