Introduction. The epidemiological and clinical patterns of COVID-19 are not fully known, especially among children. Serologic surveys indicate children of all ages were sensitive to COVID-19. Aim of the study: Evaluation of the clinical, epidemiological and evolutionary peculiarities of COVID-19 in children hospitalized in the Municipal Clinical Hospital of Contagious Diseases for Children (MCHCDC). Methods. Descriptive transversal epidemiological study was conducted, included all children (n=1326) hospitalized with COVID-19 from March, 2020 to March, 2021 in the MCHCDC. Results. School and preschool age were mostly of children, the infection occurred through family contact (62.0%). Moderate forms of the disease prevailed. Complications and comorbidities were detected in 990 (74.6%) patients: pneumonia (22.0%), including acute respiratory failure I-II (8.6%), bronchitis (5.6%), toxic infectious heart disease (1.5%), central nervous system damage (1.5%), toxic hepatitis (2.1%), pancreatitis (1.2%), others (40.6%). The elimination of SARS-CoV-2 RNA in the nasopharyngeal swab varied, the shortest in children 0-3 years (by the 15th day of illness onset), the longest – children of 11-18 years, not depend on the severity of the disease. The treatment complied with the national clinical protocol. Conclusions. Clinical and evolutionary particularities evaluation of COVID-19 is one of the most important conditions in developing of therapeutic management in the paediatric.