Introduction. Informational support systems have demonstrated their practical utility in the era of medicine digitization. After studying the latest achievements in the field, the initiative team from SUMPH "Nicolae Testemițanu" set out to build and implement an information system within the project "Information record of bio-specimens within SUMPh Biobank "Nicolae Testemitsanu" (Project 21.70086.37ȘD). Material and methods. Relevant articles were searched in PubMed and EMBase databases from 2018 to March 2023 according to the keywords "biobank" (n=217), "informational system" (n=3040), "biorepositories" (n=18), as well as their combinations (n=820). Results. After analyzing the search results, a number: 820 publications were identified by the keywords used by the authors. Publications from the authors were compared to exclude duplicates. The collection was reviewed and articles were filtered by title and abstract content. The remaining articles were assessed in full to exclude case-control studies or articles without relevant conclusions. Conclusions. Starting from the processed publications, it is obvious that information systems can have a decisive role in the modernization of biobanks and medical records by ensuring the integrity and quality of biological data, promoting and increasing the efficiency of scientific research. Information systems also encourage collaboration between biomedical research entities. The academic environment also touches on the issue of ensuring the confidentiality and security of data which is particularly important in the current era of medicine digitization. Therefore, the development and implementation of information systems in the activity of biobanks in general and in the SUMPH "Nicolae Testemițanu" biobank particularly, can exponentially increase the impact of these institutions in the practice of personalized medicine and the advancement to the stage of preventing health problems.