Introduction. Medical rehabilitation programs can have a significant impact on post-COVID-19 patients suffering from musculoskeletal pain by improving joint mobility and reducing pain, which can improve quality of life. Aim of the study. Estimating the impact of medical rehabilitation programs on post-COVID-19 patients with musculoskeletal pain. Material and Methods. Musculoskeletal functional impairments were assessed in 124 patients with SARS-Cov-2 infection and musculoskeletal pain. Pain according to the Visual Analogue Scale and Health Questionnaire - EQ-5D-5L were assessed initially and after the rehabilitation interventions. Results. Musculoskeletal pain was initially detected in 84.4% of cases, of which 16.2% of cases presented insignificant pain, 49.2% of cases moderate pain and 19.1% of cases severe pain. After the rehabilitation interventions, pain decreased in 38.4% of cases, of which 15.3% of cases presented moderate pain and 26.1% of cases - insignificant pain and 1% of cases severe pain. Health questionnaire - EQ-5D-5L initially presented level-1 2.41%, level 2- 22.5%, level 3-68.5%, level 4-5.6%, level 5- 0.80%. Final level 1 4.8%, level 2- 44.3%, level 3 -45.1%, level 4- 4.8%, level 5- 0.80%. Conclusion. Medical rehabilitation programs can have a significant positive impact on post-COVID-19 patients suffering from musculoskeletal pain by improving baseline functional status, reducing pain, and improving quality of life.