Introduction. Bullous pemphigoid is an autoimmune chronic blistering disorder manifested clinically through bullous, urticarial, and itchy skin eruption, which rarely involves mucous membranes. Disease results of immunoglobulin G and activated T lymphocytes depositions at the basement membrane level, leading to eosinophils inflammation resulting in subepidermal cavity formation. Bullous pemphigoid is common among elderly immunocompetent people. Material and methods. The clinical case of an HIV infected young woman manifesting itchy inflammatory blistering skin condition. Results. We present a case of 23-year-old female patient who developed an extremely itching, even painful disseminated papular and bullous skin eruptions involving her face, trunk, external surfaces of upper and lower limbs with spared mucous membranes. She denied any history of medicines intake or infectious disease. Patient was tested positive for HIV infection and admitted at National Hospital of Dermatology and Communicable Diseases. Systemic treatment with prednisolone at a dose of 1mg/kg/day administered during almost a week haven’t shown any skin improvement. Blood smear examination shown evident leukocytosis with increased ESR. No acantholytic cells, neither eosinophils were found in bullous exudate. Histopathology report shown subepidermal bulla with eosinophil microabscesses leading to bullous pemphigoid. Patient received a few 5-days courses of Dapsone with remarkable improvement of skin rash evolution. Conclusions. According to literature data bullous pemphigoid isn’t common among HIV patients especially of young age being related to antiretroviral intake and positively responding to systemic steroids. In our case no drug relationship was established, skin eruptions receded under sulphone treatment.