Introduction. The oral cavity is a major indicator in assessing the quality of systemic function of the entire body. The disorders of the lingual mucosa are of particular interest, as they reflect both oral and general health status and are often the preferred site for the first manifestations of systemic diseases. Manifestations localized in the tongue area are frequently encountered and can present with a diverse clinical picture - ranging from changes in color to desquamative glossitis. Desquamation of the tongue epithelium is common in disorders of the gastrointestinal and nervous systems, metabolic disorders, collagenosis, dermatitis, anemias, etc. It is caused by trophic disturbances that occur in the submucosal layer, which can be initiated by inflammation, allergy, autonomic changes, etc. Material and Methods. Based on the analysis of the results of the complex clinical and laboratory study, the clinical forms of desquamative glossitis (dysbiotic or microbial, mycotic, neurogenic, allergic, mixed) were highlighted. Considering the pathogenetic factors, conditioned by the presence of general pathologies, which develop the types of desquamative glossitis, the diagnosis and management of complex treatment become individualized. Results. The proposed diagnostic methodology and the elaborated treatment regimen of desquamative glossitis allowed for achieving a desired therapeutic effect. The influence on the pathogenetic mechanisms at the beginning of treatment contributes to the reduction of subjective data, rapid epithelialization of the desquamated area. Conclusions. The clinical and laboratory data confirm the reduction of mucosal immunity dysfunction, restoration of oral microflora, and normalization of capillary microcirculation through differentiated complex treatment of desquamative glossitis.