Plants with possible action on alzheimer disease: phytochemical and biological studies
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Ultima descărcare din IBN:
2024-01-24 21:47
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633.88 (111)
Plante aromatice. Condimente. Plante aleaginoase. Plante colorante. Plante tanante. Plante medicinale (433)
SM ISO690:2012
IONESCU, Alexandra-Mariana, BOTEZATU, Andreea-Viorica, BUSUIOC, Anna, IANCU, Alina-Viorica, FURDUI, Bianca, DINICA, Rodica-Mihaela. Plants with possible action on alzheimer disease: phytochemical and biological studies. In: Modern Trends in the Agricultural Higher Education: dedicated to the 90th anniversary of the founding of higher agricultural education in the Republic of Moldova, 5-6 octombrie 2023, Chişinău. Chişinău: Tehnica-UTM, 2023, p. 22.
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Modern Trends in the Agricultural Higher Education 2023
Conferința "Modern Trends in the Agricultural Higher Education"
Chişinău, Moldova, 5-6 octombrie 2023

Plants with possible action on alzheimer disease: phytochemical and biological studies

CZU: 633.88

Pag. 22-22

Ionescu Alexandra-Mariana, Botezatu Andreea-Viorica, Busuioc Anna, Iancu Alina-Viorica, Furdui Bianca, Dinica Rodica-Mihaela
 
"Dunarea de Jos" University of Galati
 
 
Disponibil în IBN: 18 decembrie 2023


Rezumat

Alzheimer’s disease (AD) is a neurodegenerative disorder and represents the most common type of dementia among elderly people. Thus far, oxidative stress, acetylcholine (ACh) low levels, the imbalance of metals metabolism and also the deposits of β-amyloid (Aβ) have been considered to play an important role in AD pathogenesis. Synaptic dysfunction, tau protein hyperphosphorylation and aggregation, neuroinflammation, and oxidative stress would then follow, leading eventually to neuronal death and neurotransmitter deficits. The first and so far, sole marketed anti-Alzheimer drugs are the AChE inhibitors (donepezil, rivastigmine, and galantamine), which increase the ACh levels; these drugs, however, are effective only for symptomatic treatment of AD, since they are not able to prevent the progression of the disease. In the past years, there has been intense research activity for developing drugs able to inhibit Aβ formation or aggregation. Therefore, therapies with combination of drugs or the development of multitarget anti-Alzheimer drugs has become a primary objective. Our research focuses on this type of molecular recombination based on plant extracts with antioxidant, anticoagulant and antimicrobial potential. In this work we have evaluated four medicinal plants in the mixture from the point of view of antioxidant, antimicrobial and anticoagulant properties in order to study them later as possible alternatives in Alzheimer's disease.

Cuvinte-cheie
Alzheimer disease, Antimicrobial activity, anticoagulant effect, polyphenol compounds