Objective: The study objective was to assess the neuropsychiatric profi le in Moldavian Parkinson’s diseasepatients with chronic pain. Background: Psychological factors can infl uence both the clinical picture and health related quality of life inpatients with PD. Because anxiety and depression are treatable conditions, early diagnosis and treatmentmay help to improve quality of life in these patients. Methods: We have included 140 consecutive PD patients from a tertiary care center, 73 patients withchronic pain and 67 without it, including 79 (56.4%) men and 61 (43.6%) women. All patients were assessedwith UPDRS scale, Spielberger Trait Anxiety Inventory, Beck Depression Inventory and Parkinson’s diseaseQuestionnaire 39 (PDQ-39), other collected variables being age, treatment duration, age at motor onset, PDphenotype and H&Y staging. Chronic pain was analyzed using a structured interview questionnaire.Windows Offi ce Excel 2007 program was used for statistical analysis. Results: The majority of patients presented with musculoskeletal pain (60 cases or 42.8%), 5 (3.6%) – withradicular pain, 4 (2.8%) cases presented dystonic pain and 16 (11.4%) cases have had headache. Reactiveanxiety had higher values in patients with chronic pain vs. without pain (35.73±0.94 vs. 31.77±0.86, p<0.01),the same was found for trait anxiety (52.31±0.85 vs. 48.0±0.90, p<0.001). Anxiety scores correlated withpain intensity (r=0.29, p<0.01) and quality of life scores (r=0.4, p<0.001), but not with measures of diseaseseverity. Beck depression score was higher in PD patients with chronic pain (9.49±0.64 vs. 6.31±0.51,p<0.001) and correlated statistically signifi cant with pain intensity (r=0.36, p<0.001). There was a moderatecorrelation between depression and motor scores (r=0.43, p<0.001) and depression and health relatedquality of life (r=0.65, p<0.001). This study underlies the importance of addressing neuropshychiatric disturbances such as anxiety anddepression in patients with PD and chronic pain, since they contribute to both clinical picture of pain andhealth related quality of life. To cite this abstract in AMA style: G. Pavlic, I. Moldovanu, N. Diaconu, L. Rotaru. Neuropsychiatric disturbances in Parkinson’s diseasepatients’ with chronic pain [abstract]. Mov Disord. 2016; 31 (suppl 2).https://www.mdsabstracts.org/abstract/neuropsychiatric-disturbances-in-parkinsons-disease-patients-with-chronic-pain/. Accessed December 4, 2023. MDS Abstracts - https://www.mdsabstracts.org/abstract/neuropsychiatric-disturbances-in-parkinsons-disease-patients-with-chronic-pain/