Introduction. Physical and rehabilitation medicine is one the core support for the patients with Chronic lumbar musculoskeletal pain. Recovery and physical medicine interventions can have a significant impact on patients, which can improve quality of life. Aim of the study: To estimate the impact of rehabilitation interventions on patients with chronic lumbar musculoskeletal pain. Material and Methods. 146 patients with chronic lumbar musculoskeletal pain were evaluated. All the patients were assessed through evaluation tools: Visual Analogue Scale for pain intensity, Roland-Morris Disability Questionnaire (RMDQ)and Health Questionnaire - EQ-5D-5L were assessed at baseline and after the rehabilitation interventions. Results: Musculoskeletal pain was initially detected in 85.6% of cases, of which 16.4% of cases presented insignificant pain, 51.1% of cases moderate pain and 18.1% of cases severe pain. After the rehabilitation interventions the pain decreased in 36.4% cases, of which 14.2% cases presented moderate pain and 21.1% cases insignificant pain and 1.1% cases severe pain. Health questionnaire - EQ-5D-5L initially presented level-1 1.23%, level 2- 23.5%, level 3 -69.5%, level 4-4.9%, level 5- 0.87 %. Final level 1 4.8%, level 2- 44.3%, level 3 45.1%, level 4- 4.8%, level 5- 0.80%. Assessment of disability due to chronic lumbar musculoskeletal pain assessed by the RMDQ showed a decrease to a mean value of 14,0 to 10,0 points, Conclusion. Medical rehabilitation interventions can have a significant positive impact on patients with chronic lumbar musculoskeletal pain by improving initial functional status, reducing pain and improving quality of life.