Quinoline-sulfonamide-complexes with variously metals, especially M2+, are a relatively new class of compounds with potential practical interest as fluorescent materials (having fotoluminiscent properties) and also as drugs (having a large variety of biological activities such as antibacterial, antifungal, antiprotozoals, etc.). The emphasis of this work was to obtain hybrid quinoline – sulfonamide - complexes with antimicrobial activity. The synthesis of the hybrid derivatives is direct and efficient, in two steps: acylation of variously amino-quinoline followed by metal complexation with different metals M2+ (Zn2+, Cu2+, Co2+, Cd2+, Ni2+, Pd2+). Following this experimental setup several series of synthetic hybrid quinoline – sulfonamide - complexes was obtained. The hybrid complexes were characterized by IR and NMR spectroscopy, elemental analysis and X-ray diffraction on single crystal. The antibacterial and antifungal activity was determined against gram positive bacteria Staphylococcus aureus ATCC25923, gram negative bacteria Escherichia coli ATCC25922 and fungus Candida albicans ATCC10231. The obtained data from the antimicrobial assay reveal that some of the obtained hybrids have a very good antimicrobial and antifungal activity.