In the last centuries, the species requested by medicinal plants are introduced into culture. The aim of the research is to study seed germination under monoculture conditions. The collection of medicinal and aromatic plants includes 93 botanical taxa of plants grown in monoculture. The collection was divided into 3 groups according to the ripeness of the seeds: early ripe - the seeds ripen in June, the first decade of July; mid-season - seed ripening occurs in july-august and late-ripening plants in which seeds ripen in september-october. The growing season of plants usually begins in march and ends in october. Representatives of the group of early ripening plants include two species of Rumex (acetosella and teanshanicum L.), Salvia officinalis L., and Thymus vulgaris L. Seed ripening begins at the end of June and continues until the first decade of July. In dry years, the average seed germination is 68%. However, in Rumex it reaches 85–90%. We note that the germination of seeds in Rumex also decreases by 10%. However, in Salvia officinalis, seed germination was quite low and in moderate drought conditions is 49%. The ripening of seeds in species of medium ripeness begins in august, and it coincides with the onset of the dry period. The seed germination averages 47% in years with moderate drought. Low germination, up to 20%, was recorded in Tanacetum vulgare L. In dry years, seed germination in this group decreased to 37%. Tanacetum is especially affected by drought. In such years, plant leaves are shed, inflorescences are small, seed germination is 2–4%. The group of late plants includes Origanum vulgare L., Satureja montana L., Datura stramonium L., and Foeniculum vulgare L. Seed ripening time occurs in october-november. We note that the seeds of plants of this group have the highest germination rate and it reaches 60% with moderate drought and 42% with severe drought. Conclusion. Seed germination of medicinal plants of three groups of maturity was studied. We note that seed germination is sharply reduced under the influence of summer drought, especially in plants of the middle ripeness group, in which the period of seed growth and development coincides with the period of severe drought.