Predictions associated with the global climate change assume a considerable yield loss but also a widespread distribution of pathogens associated with the fungal agent complex in cereal agroecosystems worldwide. Thus, the indices of diversity and dominance of Alternaria, Drechslera/Helminthosporium and Fusarium agents show increased harmfulness in the agrocenosis of cereal crops (Lupascu, 2016). The present study was carried out to estimate the response of local wheat genotypes to the simultaneous action of biotic and abiotic stress in the early stages of growth and to use sources with a high level of adaptability in endurance improvement programs. The investigation was done on the local winter wheat genotypes Moldova 614, Moldova 66, L M5/M./O and L M79/M5. The seeds sterilized and treated for 18 hours with culture filtrates of strains of the fungi A. alternata, D. sorokiniana and F. solani were subjected to 2 treatments: water (control variant) and polyethylene glycol solution (PEG 6000, 20%). Germination parameters, root length and stem length were investigated. The integral seed vigor index (SVI) was calculated. Genotype Moldova 614 and L M79/M5 showed medium resistance, but also sensitivity in response to FC F. solani and D. sorokiniana. Whereas, on the water-restricted background, only D. sorokiniana metabolites produced a strong reduction in root and stem length showing an increased sensitivity of the stem. The action of F. solani strains 1 and 3 facilitated the maintenance of the IVS index on PEG 20% background, which confirmed the previous results regarding the high stability of F. solani fungi under drought conditions. Genotypes Moldova 66 and L M5/MO showed medium resistance and high resistance for the investigated characters in response to most of the targeted pathogens. The simultaneous action of the stressful agents produced the reduction of germination, but the growth of the stem at the level of the control variant. The phenomenon led to the stability of the IVS index both in the FC variant, but also in the FC x PEG interaction variant.