The Peculiarities of Circadian Rhythms and their Implications on Parkinson’s Disease
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ROTARU, Lilia, CEBUC, Madalina, LUPUŞOR, Adrian, GROSU, Oxana, VOVC, Victor, LOZOVANU, Svetlana, CARAUSU, Ghenadie, GROPPA, Stanislav. The Peculiarities of Circadian Rhythms and their Implications on Parkinson’s Disease. In: IFMBE Proceedings: Nanotechnologies and Biomedical Engineering, Ed. 6, 20-23 septembrie 2023, Chişinău. Chişinău: Springer Science and Business Media Deutschland GmbH, 2023, Ediția 6, p. 75. ISBN 978-9975-72-773-0..
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IFMBE Proceedings
Ediția 6, 2023
Conferința "6th International Conference on Nanotechnologies and Biomedical Engineering"
6, Chişinău, Moldova, 20-23 septembrie 2023

The Peculiarities of Circadian Rhythms and their Implications on Parkinson’s Disease


Pag. 75-75

Rotaru Lilia1, Cebuc Madalina2, Lupuşor Adrian21, Grosu Oxana1, Vovc Victor12, Lozovanu Svetlana2, Carausu Ghenadie2, Groppa Stanislav2
 
1 Diomid Gherman Institute of Neurology and Neurosurgery,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
 
Disponibil în IBN: 12 octombrie 2023


Rezumat

Unsettling epidemiological data suggest Parkinson’s disease as the second most common neurodegenerative disorder worldwide. The worries persist as there is a demographic tendency towards the ageing of the population as the life expectancy rises. Simultaneously, circadian rhythm disruptions become more frequent as artificial life sources multiply in our daily lives. Thus, the interest of this study resides in determining the traits the endogenous clock has in the context of Parkinson’s. In order to reach this aim, a case control approach was selected which helped identify the associations between altered sleep quality and the disease (p=0.007) along with the worsening of the motor dysfunctions (p=0.029). Additionally, chronotype based variances in symptomatology’s severity was observed – worst outcomes remarked in morning individuals. Furthermore, the effect light, as main zeitgeber, exerts in diagnosed subjects was assessed and completed with from complementary studies evaluating its uses as a therapeutic tool. The end point of this paper was to attract attention upon an insufficiently researched topic, as are circadian rhythms disruptions in Parkinson’s disease, since they only recently acquired a diagnostical relevance as prodromal non-motor symptoms. Correspondingly, we wanted to incite researchers from different fields to study ways of using the biological clock’s peculiarities to enhance diagnosed patients’ lives through a transdisciplinary approach.