Background: According to the literature, the history of hirudotherapy includes several millenniums. With the development of science, researches in medicine have resulted in rapid and quite good treatment of acute diseases. In this way, in a short period of time a strong pharmaceutical industry, which proposes large amounts of synthetic drugs,has been developed. As a result, the share of natural remedies has considerably decreased, and the specialists of this field were essentially distressed. Today we observe that modern medicine rediscovers hirudotherapy. The leeches possess a mechanism that locks the system of hemostasis of the donor, represented by biologically active substances, secreted by the salivary glands. Due to these substances, hirudotherapy has many therapeutic effects. As mentioned before, hirudotherapy acts on the human body through general, local and bioenergetical effects. Conclusions: First of all, zonality of curative effect is determined by regional adjusting of blood and lymphatic circulation. Therefore, the local action is the most important manifestation of hirudotherapy. The general action is based on the application of leeches in certain reflexogenic areas, arranged to the skin, and in regions of anastomoses between the deep and superficial venous system. In this context, the role of clinical anatomy is essential in determination of the points and areas where leeches are applied.