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Articolul precedent |
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182 0 |
SM ISO690:2012 RUPPÉ, Etienne, LIXANDRU, Brânduşa Elena, COJOCARU, Radu, BURDUNIUC (POPA), Olga, NOI, Autori. Relative fecal abundance of extended-spectrum-β-lactamase-producing Escherichia coli strains and their occurrence in urinary tract infections in women. In: Antimicrobial Agents and Chemotherapy, 2013, vol. 57, pp. 4512-4517. ISSN 0066-4804. DOI: https://doi.org/10.1128/AAC.00238-13 |
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Antimicrobial Agents and Chemotherapy | |
Volumul 57 / 2013 / ISSN 0066-4804 /ISSNe 1098-6596 | |
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DOI:https://doi.org/10.1128/AAC.00238-13 | |
Pag. 4512-4517 | |
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Extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL E. coli) strains are of major concern because few antibiotics remain active against these bacteria. We investigated the association between the fecal relative abundance (RA) of ESBL-producing E. coli (ESBL-RA) and the occurrence of ESBL E. coli urinary tract infections (UTIs). The first stool samples passed after suspicion of UTI from 310 women with subsequently confirmed E. coli UTIs were sampled and tested for ESBL-RA by culture on selective agar. Predictive values of ESBL-RA for ESBL E. coli UTI were analyzed for women who were not exposed to antibiotics when the stool was passed. ESBL E. coli isolates were characterized for ESBL type, phylogroup, relatedness, and virulence factors. The prevalence of ESBL E. coli fecal carriage was 20.3%, with ESBL E. coli UTIs being present in 12.3% of the women. The mean ESBL-RA (95% confidence interval [CI]) was 13-fold higher in women exposed to antibiotics at the time of sampling than in those not exposed (14.3% [range, 5.6% to 36.9%] versus 1.1% [range, 0.32% to 3.6%], respectively; P<0.001) and 18-fold higher in women with ESBL E. coli UTI than in those with another E. coli UTI (10.0% [range, 0.54% to 100%] versus 0.56% [range, 0.15% to 2.1%[, respectively; P<0.05). An ESBL-RA of[removed] |
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Cuvinte-cheie MeSH Adolescent, adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacterial Load, Bacterial Typing Techniques, beta-Lactamases, Cross-Sectional Studies, Escherichia coli, Escherichia coli Infections, Feces, female, gene expression, Humans, middle aged, urinary tract, Urinary tract infections, Virulence Factors EMTREE drug terms agar, virulence factor EMTREE medical terms adolescent, adult, Aged, article, cross-sectional study, extended spectrum beta lactamase producing Escherichia coli, feces culture, female, human, major clinical study, predictive value, priority journal, urinalysis, urinary tract infection |
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